Visible-light-mediated radical difunctionalization of alkenes with aromatic aldehydes†

IF 2.7 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2025-01-28 DOI:10.1039/d4ob02090a
Zhenhua Xu , Tao Geng , Jun Du , Youpeng Zuo , Xiaoxiao Hu , Lin Liu , Zhiqiang Shi , Huawen Huang
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Abstract

We have developed a visible-light-mediated three-component tandem reaction of aromatic aldehydes with acrylates using a Hantzsch ester as the hydrogen atom transfer reagent, generating diethyl pentanedioate products in a one-pot synthesis. The reaction facilitates direct formation of acyl groups from the corresponding aldehydes, which are subsequently coupled successively to two molecules of acrylate in a Giese addition.

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可见光介导的烯烃与芳香族醛自由基双官能化反应。
我们开发了一种可见光介导的芳香醛与丙烯酸酯的三组分串联反应,使用Hantzsch酯作为氢原子转移试剂,在一锅合成中生成了戊二酸二乙酯产品。该反应有利于从相应的醛直接形成酰基,随后在Giese加成中连续偶联到两个丙烯酸酯分子。
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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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