The thalamus: Structure, function, and neurotherapeutics

IF 6.9 2区 医学 Q1 CLINICAL NEUROLOGY Neurotherapeutics Pub Date : 2025-03-01 DOI:10.1016/j.neurot.2025.e00550
Lara V. Marcuse , Mackenzie Langan , Patrick R. Hof , Fedor Panov , Igancio Saez , Joohi Jimenez-Shahed , Martijn Figee , Helen Mayberg , Ji Yeoun Yoo , Saadi Ghatan , Priti Balchandani , Madeline C. Fields
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Abstract

The complexity and expansive nature of thalamic research has led to numerous interventions for varied disease states. At the same time, this complexity along with siloed areas of study can hinder a comprehensive understanding. The goal of this paper is to give the reader a broader and more detailed perspective on the thalamus. In order to accomplish this goal, the paper begins with a summary of the function, electrophysiology, and anatomy of the normal thalamus. With this foundation, thalamic involvement in neurological diseases is discussed with a focus on epilepsy. Therapeutic interventions in the thalamus for epilepsy as well as movement disorders, psychiatric conditions and disorders of consciousness are described. Lastly limitations in the field and future models of data sharing and cooperation are explored.
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丘脑:结构、功能和神经疗法。
丘脑研究的复杂性和扩张性导致了对不同疾病状态的大量干预。与此同时,这种复杂性以及孤立的研究领域会阻碍全面的理解。本文的目的是让读者对丘脑有一个更广泛、更详细的认识。为了实现这一目标,本文首先概述了正常丘脑的功能、电生理学和解剖学。在此基础上,丘脑参与神经系统疾病的讨论,重点是癫痫。在丘脑治疗干预癫痫以及运动障碍,精神状况和意识障碍的描述。最后,探讨了该领域的局限性和未来的数据共享与合作模式。
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来源期刊
Neurotherapeutics
Neurotherapeutics 医学-神经科学
CiteScore
11.00
自引率
3.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities. The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field. Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.
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