{"title":"CNS drug delivery improves chemotherapy","authors":"Ian Fyfe","doi":"10.1038/s41582-025-01070-1","DOIUrl":null,"url":null,"abstract":"<p>Glioblastoma-associated macrophages (GAMs) have been effectively targeted with chemotherapy drugs that were modified to cross the blood–brain barrier in new research. The drugs camptothecin and resiquimod were conjugated to a tandem peptide that binds to low-density lipoprotein receptor-related protein 1, thereby facilitating their transport into the brain. Once inside the CNS, the drugs switched the phenotype of GAMs from tumour-supporting to tumour-inhibiting, thereby improving the sensitivity of glioblastoma to chemotherapy.</p>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"1 1","pages":""},"PeriodicalIF":28.2000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41582-025-01070-1","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Glioblastoma-associated macrophages (GAMs) have been effectively targeted with chemotherapy drugs that were modified to cross the blood–brain barrier in new research. The drugs camptothecin and resiquimod were conjugated to a tandem peptide that binds to low-density lipoprotein receptor-related protein 1, thereby facilitating their transport into the brain. Once inside the CNS, the drugs switched the phenotype of GAMs from tumour-supporting to tumour-inhibiting, thereby improving the sensitivity of glioblastoma to chemotherapy.
期刊介绍：
Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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