{"title":"Neurogenesis altered by disease and stimulation","authors":"Ian Fyfe","doi":"10.1038/s41582-025-01068-9","DOIUrl":null,"url":null,"abstract":"<p>Neurogenesis in the subventricular zone (SVZ) is altered in neurodegenerative diseases and activated by deep brain stimulation, new research suggests. Analysis of postmortem brain tissue showed that the SVZ was thinner in people with Parkinson disease (PD) than in people without neurodegenerative disease. By contrast, the SVZ was thicker in people with Huntington disease and in people with PD who had received deep brain stimulation. In both cases, thickening of the SVZ was accompanied by a high density of adult neural stem cells, indicating activation of neurogenesis.</p>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"11 1","pages":""},"PeriodicalIF":28.2000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41582-025-01068-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Neurogenesis in the subventricular zone (SVZ) is altered in neurodegenerative diseases and activated by deep brain stimulation, new research suggests. Analysis of postmortem brain tissue showed that the SVZ was thinner in people with Parkinson disease (PD) than in people without neurodegenerative disease. By contrast, the SVZ was thicker in people with Huntington disease and in people with PD who had received deep brain stimulation. In both cases, thickening of the SVZ was accompanied by a high density of adult neural stem cells, indicating activation of neurogenesis.
期刊介绍：
Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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