A roadmap to precision medicine through post-genomic electronic medical records

IF 15.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2025-02-17 DOI:10.1038/s41467-025-56442-4
Kevin M. Mendez, Stacey N. Reinke, Rachel S. Kelly, Qingwen Chen, Mark Su, Michael McGeachie, Scott Weiss, David I. Broadhurst, Jessica A. Lasky-Su
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Abstract

The promise of integrating Electronic Medical Records (EMR) and genetic data for precision medicine has largely fallen short due to its omission of environmental context over time. Post-genomic data can bridge this gap by capturing the real-time dynamic relationship between underlying genetics and the environment. This perspective highlights the pivotal role of integrating EMR and post-genomics for personalized health, reflecting on lessons from past efforts, and outlining a roadmap of challenges and opportunities that must be addressed to realize the potential of precision medicine.

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通过后基因组电子医疗记录实现精准医疗的路线图
整合电子医疗记录(EMR)和精确医疗的基因数据的承诺在很大程度上是不够的,因为它忽略了环境背景随着时间的推移。后基因组数据可以通过捕捉潜在基因和环境之间的实时动态关系来弥补这一差距。这一观点强调了整合电子病历和后基因组学以实现个性化健康的关键作用,反思了过去努力的教训,并概述了实现精准医疗潜力必须解决的挑战和机遇的路线图。
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来源期刊
Nature Communications
Nature Communications Biological Science Disciplines-
CiteScore
24.90
自引率
2.40%
发文量
6928
审稿时长
3.7 months
期刊介绍: Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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