Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization.

IF 5.9 2区医学 Q1 IMMUNOLOGY Frontiers in Immunology Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI:10.3389/fimmu.2025.1525466

Zhewei Dong, Yingli Fu, Zhongming Cai, Hao Dai, Yucang He

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Abstract

Adipose-derived mesenchymal stem cells (ADSCs) exhibit superior immunomodulatory properties and have broad therapeutic applications. They induce macrophage M2 polarization for anti-inflammatory responses. Exosomes derived from ADSCs (ADSC-EXOs) exhibit biological functions similar to those of ADSCs but can circumvent the limitations associated with cellular injection therapies. Potent anti-inflammatory substances contained in exosomes include the glycoprotein MFGE8, the cytokines such as prostaglandin E2, IL-6, and IGF, as well as non-coding nucleotides (miR-451a, miR-23, miR-30d-5p, let-7, lncRNA DLEU2, circRps5, Circ-Ptpn4, and mmu_ circ_0001359). The anti-inflammatory and immunomodulatory properties of these exosomes provide new perspectives for therapeutic approaches for graft inflammation, bone healing, acute lung injury, kidney stones, myocardial infarction, and diabetes-related diseases. This review summarizes the contents and functions of ADSC-EXOs, outlines their properties and the characteristics of macrophage phenotypes, and emphasizes their impact on macrophage polarization and their contribution to immune-related diseases.

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脂肪源性间充质干细胞源性外泌体调控巨噬细胞极化的研究进展。

脂肪源性间充质干细胞（ADSCs）具有优越的免疫调节特性，具有广泛的治疗应用。它们诱导巨噬细胞M2极化以达到抗炎反应。来源于ADSCs的外泌体（ADSC-EXOs）表现出与ADSCs相似的生物学功能，但可以规避与细胞注射疗法相关的限制。外泌体中含有的有效抗炎物质包括糖蛋白MFGE8、细胞因子如前列腺素E2、IL-6和IGF，以及非编码核苷酸（miR-451a、miR-23、miR-30d-5p、let-7、lncRNA DLEU2、circRps5、Circ-Ptpn4和mmu_ circ_0001359）。这些外泌体的抗炎和免疫调节特性为移植物炎症、骨愈合、急性肺损伤、肾结石、心肌梗死和糖尿病相关疾病的治疗提供了新的视角。本文综述了adsc - exo的内容和功能，概述了adsc - exo的性质和巨噬细胞表型特征，重点介绍了adsc - exo对巨噬细胞极化的影响及其在免疫相关疾病中的作用。

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来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.