Diapause hormone receptor affects larval growth and embryonic development in the multivoltine strain of Bombyx mori.

IF 2.9 1区 农林科学 Q1 ENTOMOLOGY Insect Science Pub Date : 2025-02-18 DOI:10.1111/1744-7917.13507
Wenhui Jing, Yun Gao, Yinghui Li, Yue Jin, Yanyan Zhou, Yusong Xu, Huabing Wang
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Abstract

Diapause is a programmed developmental arrest process in insects. Diapause can occur at various stages of insect development and is frequently restricted to a specific developmental stage within a single species. In Bombyx mori, embryonic diapause is elicited by the diapause hormone (DH) and DH receptor (DHR) in diapause strains. Nevertheless, the regulatory mechanism through which BmDHR functions as a G protein-coupled receptor (GPCR), to exert other physiological functions in nondiapause silkworms, remains unclear. In this study, we found that BmDHR had 7 alternative splice isoforms. A knockout experiment confirmed that BmDHR mediated the transduction of diapause signals. Interestingly, the loss of BmDHR caused partial precocious metamorphosis and an embryo-lethal phenotype in nondiapause silkworms. An assessment of global transcriptional patterns revealed that BmDHR knockout affected physiological responses induced by manifold cellular processes, including the Toll/immune deficiency (Imd), Wnt, insulin-like growth factor, Hedgehog and P38/mitogen-activated protein kinase (MAPK) signaling pathways. This study expands our knowledge of the physiological roles for DHR in insect growth and development.

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来源期刊
Insect Science
Insect Science 生物-昆虫学
CiteScore
7.80
自引率
5.00%
发文量
1379
审稿时长
6.0 months
期刊介绍: Insect Science is an English-language journal, which publishes original research articles dealing with all fields of research in into insects and other terrestrial arthropods. Papers in any of the following fields will be considered: ecology, behavior, biogeography, physiology, biochemistry, sociobiology, phylogeny, pest management, and exotic incursions. The emphasis of the journal is on the adaptation and evolutionary biology of insects from the molecular to the ecosystem level. Reviews, mini reviews and letters to the editor, book reviews, and information about academic activities of the society are also published.
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