Withdrawal: RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells.

IF 4 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Biological Chemistry Pub Date : 2025-03-01 Epub Date: 2025-02-16 DOI:10.1016/j.jbc.2024.108141
Martin J Lynch, George S Baillie, Ahmed Mohamed, Xiang Li, Charlotte Maisonneuve, Enno Klussmann, Gino van Heeke, Miles D Houslay
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在HEK293B2细胞中,RNA沉默鉴定PDE4D5是功能相关的cAMP磷酸二酯酶,与β抑制蛋白相互作用,控制蛋白激酶A/ akap79介导的β2-肾上腺素能受体转换到ERK的激活。
《华尔街日报》得出结论,图4B的第二和第三条车道来自同一源图像。原始数据无法解决《华尔街日报》的担忧。作者已决定撤回这篇文章。
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Journal of Biological Chemistry
Journal of Biological Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry
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4.20%
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期刊介绍: The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.
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