Exploring the effects of an insulin challenge on neuroimaging outcomes: A scoping review

IF 6.7 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Frontiers in Neuroendocrinology Pub Date : 2025-02-17 DOI:10.1016/j.yfrne.2025.101187

Nicolette Stogios , Sally Wu , Margaret Hahn , Zahra Emami , Janani Navagnanavel , Vittal Korann , Akash PrasannaKumar , Gary Remington , Ariel Graff-Guerrero , Sri Mahavir Agarwal

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Abstract

Emerging evidence demonstrates that insulin has a modulating effect on metabolic and cognitive function in the brain, highlighting the potential role of aberrant brain insulin signaling in the pathogenesis of various neuropsychiatric illnesses. Neuroimaging paradigms using intranasal insulin (INI) as a pharmacological challenge have allowed us to study the effects of insulin in the human brain. In this scoping review, we conducted a systematic database search to identify relevant research studies that employed an INI-based neuroimaging assay of brain insulin signaling. Thirty-six studies met inclusion criteria for this review. INI was found to significantly modulate activity and cerebral blood flow in brain regions related to homeostatic/hedonic control of food intake, as well as cognition. This review highlights the putative role of insulin signaling in the brain and the potential therapeutic value of INI in patients with mental health, addiction, and co-morbid metabolic disorders.

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探讨胰岛素刺激对神经影像学结果的影响：一项范围综述

新出现的证据表明，胰岛素对大脑的代谢和认知功能具有调节作用，突出了异常脑胰岛素信号在各种神经精神疾病发病机制中的潜在作用。使用鼻内胰岛素（INI）作为药理学挑战的神经影像学范式使我们能够研究胰岛素在人脑中的作用。在这篇范围综述中，我们进行了系统的数据库搜索，以确定采用基于脑胰岛素信号的神经成像分析的相关研究。36项研究符合本综述的纳入标准。研究发现，INI可以显著调节与食物摄入的稳态/享乐控制以及认知相关的大脑区域的活动和脑血流量。这篇综述强调了胰岛素信号在大脑中的可能作用，以及INI在精神健康、成瘾和共病代谢疾病患者中的潜在治疗价值。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.