Copper-catalyzed enantioselective propargylic [3 + 2] cycloaddition: access to oxygen heterocycles featuring a CF3-substituted quaternary stereocenter.

IF 2.9 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2025-02-19 DOI:10.1039/d4ob02043j
Shweta Rohilla, Zahid Ahmad Khan, Vinod K Singh
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引用次数: 0

Abstract

A Cu(I)-Pybox-diPh catalyzed enantioselective [3 + 2] cycloaddition reaction of CF3-substituted tertiary propargylic esters as C2-bis-electrophiles with cyclic 1,3-dicarbonyl compounds as C,O-bis-nucleophiles has been reported. The methodology furnishes a variety of optically active oxygen heterocycles containing a CF3-substituted quaternary stereocenter in good yields and enantioselectivities. Moreover, the scalability of the reaction and transformations of chiral compounds into their derivatives demonstrated the synthetic and practical relevance of the approach.

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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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