Total and Reduced Aminothiols in Blood Plasma as Biochemical Markers of the Effectiveness of Hemodialysis Therapy in Patients with End-Stage Renal Disease.

Abstract

The redox status of aminothiols in the blood plasma of 15 patients with end-stage renal disease before and against the background of hemodialysis therapy was compared with that of relatively healthy volunteers. An increase in the plasma content of total cysteine and homocysteine in patients before dialysis was revealed. An increase in the level of oxidized forms of these compounds was also noted. The hemodialysis procedure was accompanied by a significant shift of the redox status towards an increase in the reduced forms typical of healthy people. Oxidized forms of aminothiols can be used as biomarkers of uremic conditions in patients with end-stage renal disease. At the same time, the predominance of reduced forms of compounds may be an indicator of the effectiveness of renal replacement therapy, including hemodialysis.