Influence of Contact Lens Parameters on Tear Film Dynamics.

IF 2.2 4区 数学 Q2 BIOLOGY Bulletin of Mathematical Biology Pub Date : 2025-02-19 DOI:10.1007/s11538-025-01425-1
Darshan Ramasubramanian, José Luis Hernández-Verdejo, José Manuel López-Alonso
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Abstract

This study employs a computational model to simulate the dynamics of tear fluid and tear film in conjunction with contact lens motion, examining the interplay between diverse contact lens characteristics-such as material, design, and dimensions-and key ocular factors like dry eye conditions, corneal size, and blink rate. These interactions are critical for customising lens fit to maximise wearer comfort. Utilising optical measurements from a single participant, the study integrates data on tear meniscus size, blink velocity, and palpebral fissure height with sixteen different contact lens parameters, including Young's modulus, thickness, diameter, and curvature. Correlation analyses were conducted to determine the impact of these parameters on the dynamics of the tear fluid and overall tear film. Results show that the diameter and Young's modulus of the contact lens significantly influence pre-lens tear film thickness, with robust, statistically significant correlations. In contrast, lens thickness and base curve showed minimal impact, as evidenced by weak and non-significant correlations. These findings underscore the critical roles of lens diameter and Young's modulus in enhancing the stability and distribution of tear fluid, thereby improving wearer comfort and advancing contact lens design.

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隐形眼镜参数对泪膜动力学的影响。
本研究采用一个计算模型来模拟泪液和泪膜的动态与隐形眼镜的运动,研究不同的隐形眼镜特征(如材料、设计和尺寸)和关键的眼部因素(如干眼状况、角膜大小和眨眼频率)之间的相互作用。这些相互作用对于定制镜片以最大限度地提高佩戴者的舒适度至关重要。该研究利用单个参与者的光学测量数据,将撕裂半月板大小、眨眼速度和睑裂高度的数据与16种不同的隐形眼镜参数(包括杨氏模量、厚度、直径和曲率)整合在一起。进行相关分析以确定这些参数对泪液和整体泪膜动力学的影响。结果表明,隐形眼镜的直径和杨氏模量显著影响晶状体前泪膜厚度,具有统计学上显著的相关性。相比之下,透镜厚度和基底曲线显示最小的影响,证明了弱和不显著的相关性。这些发现强调了晶状体直径和杨氏模量在增强泪液稳定性和分布方面的关键作用,从而提高了佩戴者的舒适度,促进了隐形眼镜的设计。
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来源期刊
CiteScore
3.90
自引率
8.60%
发文量
123
审稿时长
7.5 months
期刊介绍: The Bulletin of Mathematical Biology, the official journal of the Society for Mathematical Biology, disseminates original research findings and other information relevant to the interface of biology and the mathematical sciences. Contributions should have relevance to both fields. In order to accommodate the broad scope of new developments, the journal accepts a variety of contributions, including: Original research articles focused on new biological insights gained with the help of tools from the mathematical sciences or new mathematical tools and methods with demonstrated applicability to biological investigations Research in mathematical biology education Reviews Commentaries Perspectives, and contributions that discuss issues important to the profession All contributions are peer-reviewed.
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