A Case of ANCA-Associated Vasculitis with Positive PR3 and MPO Antibodies.

IF 0.6 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2025-02-01 DOI:10.7754/Clin.Lab.2024.240917

Hongkun Xu, Kejie Xie

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Abstract

Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases including granulomatous polyvasculitis (GPA), microscopic polyvasculitis (MPA), and eosinophilic granulomatous polyvasculitis (EGPA). The main antigens ANCA targets are protease 3 (PR3) and myeloperoxidase (MPO). PR3-ANCA is mainly related to GPA, while MPO-ANCA is related to MPA. The presence of these antibodies is critical to the diagnosis of AAV.

Methods: A case of ANCA-associated vasculitis with PR3 and MPO antibody positive due to PTU was reported.

Results: After the patients stopped PTU, PR3 antibody gradually decreased to negative, MPO antibody was relatively stable, and the fluorescent karyotype was p-ANCA. The positive PR3 antibody in this patient was considered to be related to PTU.

Conclusion: ANCA, anti-PR3 antibody, and anti-MPO antibody are closely related to systemic vasculitis and are affected by many factors. Abnormal results in clinical work should be reviewed immediately and communicated with clinicians to avoid adverse consequences.

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PR3和MPO抗体阳性的anca相关性血管炎1例。

背景：抗中性粒细胞胞浆抗体（ANCA）相关血管炎（AAV）是一组自身免疫性疾病，包括肉芽肿性多血管炎（GPA）、显微多血管炎（MPA）和嗜酸性肉芽肿性多血管炎（EGPA）。ANCA的主要靶点抗原是蛋白酶3 （PR3）和髓过氧化物酶（MPO）。PR3-ANCA主要与GPA相关，MPO-ANCA主要与MPA相关。这些抗体的存在对AAV的诊断至关重要。方法：报告1例因PTU引起的anca相关性血管炎患者PR3和MPO抗体阳性。结果：停用PTU后，PR3抗体逐渐下降至阴性，MPO抗体相对稳定，荧光核型为p-ANCA。该患者PR3抗体阳性，考虑与PTU有关。结论：ANCA、抗pr3抗体、抗mpo抗体与全身性血管炎密切相关，受多种因素影响。临床工作中出现的异常结果应立即进行复查，并及时与临床医生沟通，避免产生不良后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.