Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans.

IF 5.2 1区医学 Q1 ENDOCRINOLOGY & METABOLISM European Journal of Endocrinology Pub Date : 2025-03-03 DOI:10.1093/ejendo/lvaf001

Francesca Galbiati, Franziska Plessow, Lacey Plummer, Mark B Campbell, Shawn Nazarloo, C Sue Carter, Rona S Carroll, Han K Kim, Sidney A Pereira, Daria Paulis, John M Davis, Karen K Miller, Ursula B Kaiser, Stephanie B Seminara, Anna Aulinas, Elizabeth A Lawson

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Abstract

Background: A clinically significant oxytocin-deficient state (OXT-D) has been established in adults with arginine vasopressin deficiency, and there is a need to develop diagnostic testing. Kisspeptin (KP) is a candidate for such a test, as KP receptors are found on oxytocinergic neurons, and KP administration increases plasma OXT in animals. We hypothesized that intravenous KP administration would increase peripheral OXT levels post-injection in healthy adults.

Methods: Kisspeptin-112-121 (KP analog, 0.24 nmol/kg bolus) was administered to 12 healthy adults (50% female). Serum OXT was measured before and 10, 20, 40, and 60 min after KP administration.

Results: Males and females did not differ significantly in age, BMI, or baseline OXT levels. Ten minutes after KP, OXT increased by 18.8% from baseline (FDR-P = .004) with a greater increase in males than females (31.9% vs 5.7%, respectively, FDR-P = .004).

Conclusions: Our data support KP as a candidate for a provocative test to identify OXT-D in males.

Clinical trial registration: Our study was registered on ClinicalTrials.gov (NCT00914823).

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人类静脉注射kisspeptin后催产素水平的性别依赖性增加。

背景：精氨酸抗利尿激素缺乏症的成人存在临床显著的催产素缺乏状态（OXT-D），需要开发诊断测试。Kisspeptin （KP）是这种测试的候选者，因为KP受体在催产素能神经元上发现，KP给药增加动物血浆OXT。我们假设静脉注射KP政府将会增加健康成人注射后外周血氧合水平。方法：12例健康成人（女性50%）口服KP-112-121 （KP类似物，0.24 nmol/kg）。分别于给药前、给药后10、20、40、60分钟测定血清OXT。结果：男性和女性在年龄、BMI或基线OXT水平上没有显著差异。KP后10分钟，OXT较基线增加18.8% (FDR-p=0.004)，男性比女性增加更多（分别为31.9%对5.7%,FDR-p=0.004）。结论：我们的数据支持KP作为识别男性OXT-D的刺激性测试的候选人。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Endocrinology 医学-内分泌学与代谢

CiteScore

9.80

自引率

3.40%

发文量

354

审稿时长

1 months

期刊介绍： European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.