Functionalized conductive polymer composites for tissue engineering and biomedical applications- a mini review.

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Frontiers in Bioengineering and Biotechnology Pub Date : 2025-02-04 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1533944

V Gayathri, Tabrej Khan, M Gowtham, R Balan, Tamer A Sebaey

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Abstract

Tissue engineering (TE) has emerged as a promising therapeutic strategy, employing artificial scaffolds to regenerate functional cardiac tissue and offering new hope for innovative treatment approaches. A straightforward method for producing biodegradable, conductive polymer-based composites involves blending conductive polymers directly with biodegradable ones. This approach's flexibility enables the development of diverse biodegradable, conductive polymer scaffolds, which have been extensively explored in tissue engineering and regenerative medicine. While this technique successfully combines the advantages of both polymer types, it may face challenges such as potential compromises in conductivity and biodegradability. This review emphasizes the potential to tailor degradation rates and conductivity by selecting appropriate polymer types and ratios, ensuring adaptability for various biomedical applications.

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.