Nanotechnology-based drug delivery system for targeted therapy of ulcerative colitis from traditional Chinese medicine: A review

IF 5.2 2区医学 Q1 PHARMACOLOGY & PHARMACY International Journal of Pharmaceutics Pub Date : 2025-02-16 DOI:10.1016/j.ijpharm.2025.125375

Chengcheng Gao, Zerun Yang, Ruirui Song, Huagang Sheng, Liqiao Zhu

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Abstract

Ulcerative colitis (UC) is a chronic autoimmune disease and seriously affects the normal life of patients. Conventional therapeutic drugs are difficult to meet clinical needs. Traditional Chinese medicine (TCM) ingredients could effectively alleviate the symptoms of UC by anti-inflammatory, anti-oxidative, regulating the gut microbiota, and repairing the colonic epithelial barrier, but their low solubility and bioavailability severely limit their clinical application. Nano-drug delivery systems (NDDS) combined with TCM ingredients is a promising option for treating UC, and they could significantly enhance the stability, solubility, and bioavailability of TCM ingredients. The review describes the anti-UC mechanisms of TCM ingredients, systematically summarizes various kinds of NDDS for TCM ingredients according to different routes of administration, and highlights the advantages of NDDS for TCM ingredients in the treatment of UC. In addition, we discuss the limitations of existing NDDS for TCM ingredients and the development direction in the future. This review will provide a basis for the future development of anti-UC NDDS for TCM ingredients.

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基于纳米技术的中药靶向治疗溃疡性结肠炎药物传递系统研究进展。

溃疡性结肠炎（UC）是一种慢性自身免疫性疾病，严重影响患者的正常生活。常规治疗药物难以满足临床需要。中药成分具有抗炎、抗氧化、调节肠道菌群、修复结肠上皮屏障等作用，可有效缓解UC症状，但其溶解度和生物利用度较低，严重限制了其临床应用。纳米给药系统（NDDS）联合中药制剂治疗UC是一种很有前景的选择，它们可以显著提高中药制剂的稳定性、溶解度和生物利用度。本文阐述了中药成分抗UC的作用机制，根据给药途径的不同，系统总结了各种中药成分的NDDS，并突出了中药成分NDDS治疗UC的优势。此外，我们还讨论了现有中药成分NDDS的局限性和未来的发展方向。本文综述将为今后中药成分抗uc nds的开发提供依据。

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来源期刊

International Journal of Pharmaceutics 医学-药学

CiteScore

10.70

自引率

8.60%

发文量

951

审稿时长

72 days

期刊介绍： The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.