Factors affecting free vancomycin concentration and target attainment of free area under the concentration-time curve.

IF 1.2 Q4 PHARMACOLOGY & PHARMACY Journal of Pharmaceutical Health Care and Sciences Pub Date : 2025-02-18 DOI:10.1186/s40780-025-00419-4

Toshiharu Urakami, Yusuke Oka, Takashi Matono, Yosuke Aoki

{"title":"Factors affecting free vancomycin concentration and target attainment of free area under the concentration-time curve.","authors":"Toshiharu Urakami, Yusuke Oka, Takashi Matono, Yosuke Aoki","doi":"10.1186/s40780-025-00419-4","DOIUrl":null,"url":null,"abstract":"Background: It has been reported that the protein binding rate of vancomycin (VCM) varies among individual patients. So, the authors investigated relevant factors that may affect free VCM concentration and target attainment of free area under the concentration-time curve (fAUC).Methods: Thirty-nine patients were included. Multiple regression analysis was performed to determine the valuable factors in the free VCM concentration, and the target attainment of area under the concentration-time curve (AUC) 400-600 mg・h/L and fAUC200-300 mg・h/L was calculated.Results: We found total protein was significant covariate for free VCM. Among 18 patients who were investigated for AUC and fAUC estimation, 9 patients (50.0%) and 12 patients (66.7%) reached AUC > 600 mg・h/L, and fAUC > 300 mg・h/L (p = 0.310), respectively.Conclusions: Total protein is a significant predictor for free VCM estimation. And the fAUC-guided TDM for VCM TDM may contribute to more strict dosing than the AUC-guided TDM in hyper- or hypo-proteinemic population.Trial registration: Retrospectively registered.","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":"11 1","pages":"13"},"PeriodicalIF":1.2000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834178/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Health Care and Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40780-025-00419-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: It has been reported that the protein binding rate of vancomycin (VCM) varies among individual patients. So, the authors investigated relevant factors that may affect free VCM concentration and target attainment of free area under the concentration-time curve (fAUC).

Methods: Thirty-nine patients were included. Multiple regression analysis was performed to determine the valuable factors in the free VCM concentration, and the target attainment of area under the concentration-time curve (AUC) 400-600 mg・h/L and fAUC200-300 mg・h/L was calculated.

Results: We found total protein was significant covariate for free VCM. Among 18 patients who were investigated for AUC and fAUC estimation, 9 patients (50.0%) and 12 patients (66.7%) reached AUC > 600 mg・h/L, and fAUC > 300 mg・h/L (p = 0.310), respectively.

Conclusions: Total protein is a significant predictor for free VCM estimation. And the fAUC-guided TDM for VCM TDM may contribute to more strict dosing than the AUC-guided TDM in hyper- or hypo-proteinemic population.

Trial registration: Retrospectively registered.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

影响游离万古霉素浓度及浓度-时间曲线下游离面积目标实现的因素。

背景：据报道，万古霉素（VCM）的蛋白结合率在个体患者中存在差异。因此，研究了影响游离VCM浓度和浓度-时间曲线下自由面积目标实现的相关因素。方法：纳入39例患者。通过多元回归分析确定游离VCM浓度的影响因素，计算出浓度-时间曲线下面积（AUC） 400-600 mg·h/L、fAUC200-300 mg·h/L的目标实现情况。结果：我们发现总蛋白是游离VCM的显著协变量。在接受AUC和fac估计调查的18例患者中，9例（50.0%）和12例（66.7%）的AUC >达到600 mg·h/L， fac >达到300 mg·h/L （p = 0.310）。结论：总蛋白是游离VCM估计的重要预测因子。在高蛋白或低蛋白人群中，与auc引导的TDM相比，fox引导的VCM TDM可能有助于更严格的给药。试验注册：回顾性注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊