Julia Casazza, Donald Tan, Mark Newcomer, Hitomi Sakano, Brandon Isaacson, Jacob B Hunter
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引用次数: 0
Abstract
Objective: To provide the first description of intratympanic bacteriophage therapy for chronic mastoiditis from multidrug-resistant Pseudomonas aeruginosa in the United States.
Patients: A 47-year-old woman with chronic mastoiditis in the setting of ciliary dysfunction from cystic fibrosis and immunosuppression from lung transplantation.
Interventions: Ten concurrent parenteral and intratympanic doses of two custom phages targeting P. aeruginosa followed by IV antibiotic therapy.
Main outcome measures: Resolution of infection confirmed by symptomatology, cultures, and imaging.
Results: At 5 months after phage treatment, the patient reported resolution of otorrhea, headaches, and hearing impairment. Subsequent cultures showed no growth.
Conclusions: Bacteriophages can enhance antibiotic activity in cases of drug-resistant chronic mastoiditis.
期刊介绍：
Otology & Neurotology publishes original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. As the foremost journal in its field, it has become the favored place for publishing the best of new science relating to the human ear and its diseases. The broadly international character of its contributing authors, editorial board, and readership provides the Journal its decidedly global perspective.
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