Poor Association Between Clinical Characteristics and Seropositivity in Children With Suspected Long COVID—A Single-Centre Study

IF 2.1 4区医学 Q1 PEDIATRICS Acta Paediatrica Pub Date : 2025-02-19 DOI:10.1111/apa.70034

S. Olsson-Åkefeldt, J. Luthander, L. Anmyr, L. Villard, S. Arnason, M. K. Kemani, E. Wållgren, S. Röstlund, M. Tingborn, M. Pettersson, E. George, M. Ryd-Rinder, O. Hertting

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Abstract

Aim

We aimed to compare characteristics and clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody positive or negative children attending a specialist outpatient clinic for suspected paediatric long COVID.

Methods

A cross-sectional study was conducted of 113 children and adolescents enrolled between 1 December 2020 to 14 September 2021 in a multidisciplinary programme. Clinical and epidemiological data were collected with standardised interviews and laboratory tests including SARS-CoV-2 spike antibody measurement.

Results

A serological link to SARS-CoV-2 infection was found in 52%. Most patients (94.7%) reported several symptoms. Fatigue, post-exertional malaise, dizziness, nausea, headache, and concentration difficulties were the most common. Seronegative children had a higher number of individual symptoms. School absence and drop-out from leisure activities was substantial in both groups with higher numbers for the seronegative group. Self-reported health was low in both groups.

Conclusion

Children attending a specialist paediatric long COVID clinic experienced multiple symptoms and poor self-reported health. The symptomatology was similar regardless of serological status, implying multifactorial causes. A multidisciplinary assessment of this cohort was essential considering the broad spectrum of symptoms displayed and their substantial impact on everyday functioning.

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疑似长冠状病毒感染儿童的临床特征与血清阳性之间相关性较差——单中心研究

目的：比较重症急性呼吸综合征冠状病毒2 （SARS-CoV-2）抗体阳性或阴性儿童在专科门诊就诊的特征和临床表现。方法：在2020年12月1日至2021年9月14日期间，113名儿童和青少年参加了一项多学科项目的横断面研究。通过标准化访谈和实验室检测（包括SARS-CoV-2刺突抗体检测）收集临床和流行病学数据。结果：52%的人与SARS-CoV-2感染有血清学联系。大多数患者（94.7%）报告了几种症状。疲劳、运动后不适、头晕、恶心、头痛和注意力不集中是最常见的。血清阴性儿童个体症状较多。在两组中，缺课和退出休闲活动的人数都很大，血清阴性组的人数更高。两组自我报告的健康状况都很低。结论：在专科儿科COVID门诊就诊的儿童出现多种症状，自我报告的健康状况较差。无论血清学状况如何，症状相似，暗示多因素病因。考虑到所表现的广泛症状及其对日常功能的重大影响，对该队列进行多学科评估是必不可少的。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries