An Australian perspective on clinical, economic and regulatory considerations in emerging nanoparticle therapies for infections.

Benjamin W Muir, Jennifer A E Payne, Jennifer H Martin, Riley O' Shea, Sarigama Rajesh, Lewis D Blackman, Hsin-Hui Shen, Chad Heazlewood, Vipul Bansal, Branwen Morgan
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Abstract

Antimicrobial resistance (AMR) poses a growing global health threat. Nanomedicine, combined with drug repurposing, may help extend the effective lifespan of current and new antimicrobials. This review, presents an Australian perspective on nanotechnology-based therapies, highlighting scientific and clinical challenges. Early consideration of the potential barriers to market access may help to accelerate research translation, regulatory approval and patient access to nano-antimicrobial (NAM) drugs for resistant pathogens, not only in Australia, but globally.

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澳大利亚对新兴的纳米颗粒治疗感染的临床、经济和监管考虑的观点。
抗菌药耐药性(AMR)对全球健康的威胁与日俱增。纳米医学与药物再利用相结合,可能有助于延长现有抗菌药物和新型抗菌药物的有效寿命。本综述从澳大利亚的视角介绍了基于纳米技术的疗法,并强调了科学和临床方面的挑战。及早考虑市场准入的潜在障碍可能有助于加快研究转化、监管审批和患者使用纳米抗菌药物治疗耐药病原体,不仅在澳大利亚如此,在全球也是如此。
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