{"title":"tRNA intron-derived small regulatory RNAs fine-tune gene expression under oxidative stress","authors":"Duo Pan, Mo-Fang Liu","doi":"10.1016/j.molcel.2025.01.026","DOIUrl":null,"url":null,"abstract":"The intron sequences of certain tRNAs are evolutionarily conserved among specific organisms, implying potential cellular functions of such tRNA introns. In this issue, Nostramo et al.<span><span><sup>1</sup></span></span> identify free introns of tRNAs (fitRNAs) in <em>S. cerevisiae</em> as small regulatory RNAs that dynamically control mRNA levels in response to oxidative stress.","PeriodicalId":18950,"journal":{"name":"Molecular Cell","volume":"13 1","pages":""},"PeriodicalIF":16.6000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.molcel.2025.01.026","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The intron sequences of certain tRNAs are evolutionarily conserved among specific organisms, implying potential cellular functions of such tRNA introns. In this issue, Nostramo et al.1 identify free introns of tRNAs (fitRNAs) in S. cerevisiae as small regulatory RNAs that dynamically control mRNA levels in response to oxidative stress.
期刊介绍：
Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.
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