Cascade Pd-Catalyzed Azide-Isocyanide Cross Coupling/Cyclization/Lactamization Reactions for the Synthesis of Tricyclic Guanidine-Containing Polyheterocycles
Xiaoming Ma*, Zijie Gao, Jiawei Niu, Sai Zhang, Lingfeng Luo, Shenghu Yan, Qiang Zhang and Wei Zhang*,
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引用次数: 0
Abstract
A one-pot synthesis of a tricyclic guanidine scaffold is developed. The azido-bearing [3 + 2] adducts are used for cascade azide-isocyanide cross-coupling/nucleophilic cyclization/lactamization to afford highly condensed polyheterocycles. A wide range of azido-containing [3 + 2] adducts and isocyanides are tolerated in the sequential reactions.
期刊介绍：
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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