Research progress in methods of acquisition, structure elucidation, and quality control of Chinese herbal polysaccharides

IF 4.9 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Chinese Journal of Natural Medicines Pub Date : 2025-02-01 Epub Date: 2025-02-20 DOI:10.1016/S1875-5364(25)60819-3
Tingting Wang , Baojie Zhu , Jing Zhao , Shaoping Li
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Abstract

The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness. However, the precise active components underlying each prescription remain incompletely understood. Polysaccharides, as a major constituent of water decoctions—the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development. The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules. This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research, focusing on methods of acquisition, structure elucidation, and quality control.
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中草药多糖的提取方法、结构解析及质量控制研究进展
中医的治疗效果由于其广泛的临床疗效历史而得到广泛认可。然而,每种处方背后的确切有效成分仍然不完全清楚。水煎法是中药最常用的制备方法,多糖作为水煎法的主要成分,可能为加深我们对中药功效原理的认识和建立中药现代发展的框架提供重要途径。与小分子多糖相比,中草药多糖结构的复杂性和多样性给其分离和分析带来了重大挑战。本文通过对多糖化学研究的最新进展进行综述,重点从多糖的获取方法、结构解析和质量控制等方面探讨了中药多糖的开发潜力。
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来源期刊
Chinese Journal of Natural Medicines
Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.50
自引率
4.30%
发文量
2235
期刊介绍: The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
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