A Markov Chain methodology for care pathway mapping using health insurance data, a study case on pediatric TBI

IF 4.9 2区 医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Computer methods and programs in biomedicine Pub Date : 2025-02-16 DOI:10.1016/j.cmpb.2025.108659
Viktor-Jan De Deken, Wilfried Cools, Helena Van Deynse, Koen Putman, Kurt Barbé
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引用次数: 0

Abstract

Background

Care pathways are increasingly used in healthcare systems globally to guide patient care and improve outcomes. These pathways offer a structured approach to managing patient care processes, potentially reducing costs and enhancing efficiency. However, the dynamic and complex nature of healthcare presents challenges in analyzing and improving these pathways, particularly due to the unique and varied patient journeys. This study focuses on the use of administrative data to map care pathways for pediatric Traumatic Brain Injury (TBI) patients, a population significantly impacted by high mortality and disability rates.

Objective

The objective of this research is to map and analyze care pathways using a novel methodology inspired by Hidden Markov chains. The study aims to overcome challenges in analyzing the dynamic and complex nature of the healthcare processes, particularly in a heterogeneous patient population. By using administrative data, the goal is to provide valuable insights into care pathways of these patients.

Methods

The study utilizes a study case dataset comprising of 4074 children admitted to Belgian hospitals for TBI in 2016, with administrative data encompassing healthcare services up to one-year post-TBI. The proposed methodology involves representing care pathways as Hidden Markov chains, where the transition between states is determined by the current medical treatment. Hierarchical clustering based on similarity of care paths, volume, and median timepoint is applied to identify subpopulations.

Results

Hierarchical clustering reveals distinct clusters, each characterized by unique care pathways. The clusters show variations in the length of care pathways, proportion of mild to severe cases, and vary with unique treatment events. Visualization of these pathways provides a comprehensive understanding of the treatment patterns within each cluster.

Conclusion

The study introduces a novel methodology for mapping care pathways. Uncovering these different care pathways enhances the understanding of the variation in care and might lead to improving the quality of care received by patients.
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背景全球医疗保健系统越来越多地采用护理路径来指导病人护理和改善疗效。这些路径提供了一种管理病人护理流程的结构化方法,有可能降低成本并提高效率。然而,医疗保健的动态性和复杂性给分析和改进这些路径带来了挑战,特别是由于病人的旅程独特而多样。本研究的重点是利用管理数据绘制儿科创伤性脑损伤(TBI)患者的护理路径图,该人群受到高死亡率和高残疾率的严重影响。这项研究旨在克服在分析医疗保健流程的动态性和复杂性方面所面临的挑战,尤其是在异质性患者群体中。该研究利用了一个研究病例数据集,其中包括 2016 年因创伤性脑损伤入住比利时医院的 4074 名儿童,其行政数据涵盖了创伤性脑损伤后一年内的医疗服务。所提出的方法包括将护理路径表示为隐马尔科夫链,其中状态之间的转换由当前的医疗决定。根据护理路径的相似性、数量和中位时间点进行分层聚类,以识别亚群。结果分层聚类显示出不同的群组,每个群组都有独特的护理路径。这些群组在护理路径的长度、轻度到重度病例的比例方面存在差异,并随独特的治疗事件而变化。通过对这些路径的可视化,可以全面了解每个群组内的治疗模式。揭示这些不同的护理路径有助于加深对护理差异的理解,并有可能提高患者接受护理的质量。
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来源期刊
Computer methods and programs in biomedicine
Computer methods and programs in biomedicine 工程技术-工程:生物医学
CiteScore
12.30
自引率
6.60%
发文量
601
审稿时长
135 days
期刊介绍: To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.
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