Recent Advancements in the Cyclization Strategies of 1,3-Enynes Towards the Synthesis of Heterocyclic/Carbocyclic Frameworks

IF 3.3 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemistry - An Asian Journal Pub Date : 2025-02-20 DOI:10.1002/asia.202401657
Akash P. Sakla, Shams Aaghaz, Dr. Shujauddin Ahmed, Naziya Neshat, Prof. Ahmed Kamal
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Abstract

1,3-Enynes have demonstrated their utility as valuable precursors to furnish a diverse range of heterocycles and carbocycles. Their unique structural characteristics enable a new toolbox to introduce requisite complexity in the molecular framework. Cyclization reaction is usually a simple and straightforward way to afford complex organic frameworks. Herein, we collated versatile cyclization strategies that have been developed by employing 1,3-enynes for the synthesis of heterocyclic and carbocyclic scaffolds. Divergent synthesis and mechanistic perspectives to define stereo-, regio- and chemo-selective outcomes of such reactions have also been highlighted.

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1,3-炔合成杂环/碳环框架的环化策略研究进展。
1,3-炔已经证明了它们作为提供各种杂环和碳环的有价值的前体的效用。它们独特的结构特征使新的工具箱能够在分子框架中引入必要的复杂性。环化反应通常是一种简单直接的合成复杂有机骨架的方法。在此,我们整理了利用1,3-炔合成杂环和碳环支架的通用环化策略。不同的合成和机制的观点来定义立体,区域和化学选择的结果,这类反应也被强调。
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来源期刊
Chemistry - An Asian Journal
Chemistry - An Asian Journal 化学-化学综合
CiteScore
7.00
自引率
2.40%
发文量
535
审稿时长
1.3 months
期刊介绍: Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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