Recent advancements in the cyclization strategies of 1,3-enynes towards the synthesis of heterocyclic /carbocyclic frameworks.

Abstract

1,3-Enynes have demonstrated their utility as valuable precursors to furnish a diverse range of heterocycles and carbocycles. Their unique structural characteristics enable a new toolbox to introduce requisite complexity in the molecular framework. Cyclization reaction is usually a simple and straightforward way to afford complex organic frameworks. Herein, we collated versatile cyclization strategies that have been developed by employing 1,3-enynes for the synthesis of heterocyclic and carbocyclic scaffolds. Divergent synthesis and mechanistic perspectives to define stereo-, regio- and chemo-selective outcomes of such reactions have also been highlighted.