The potential role of the αVβ3 integrin receptor in placental biology and normal and complicated pregnancies

Abstract

The αVβ3 receptor is a member of the integrin family of receptors, which includes 24 members involved in a variety of key biological processes. It is widely expressed in multiple cell types and is involved in cell adhesion and migration, angiogenesis and immune cell regulation. These processes play important roles in both normal placentation and placental progression through pregnancy. This review describes the potential roles of αVβ3 integrin receptor throughout gestation in normal and abnormal conditions, and the need for additional studies to better define its precise contributions.