Association of Dietary Inflammation Index with sarcopenia in adult women with nonalcoholic fatty liver disease: based on the National Health and Nutrition Examination Survey Database.

Abstract

Background: A higher Dietary Inflammatory Index (DII) is linked with an elevated risk of sarcopenia, but the relationship between the two in adult female patients with nonalcoholic fatty liver disease (NAFLD) remains uncertain.

Objective: The project was designed to probe into the relationship between DII and the risk of sarcopenia in adult female NAFLD patients.

Methods: As a cross-sectional study, this study used NAFLD data for adult women from the 2017 to 2018 National Health and Nutrition Examination Survey (NHANES) Database, with DII as the independent variable and sarcopenia as the dependent variable. The relationship between DII and sarcopenia was examined by utilizing weighted logistic regression. Restricted cubic splines (RCS) and threshold effect models were further employed to explore the nonlinear relationship between the two.

Results: We included 469 NAFLD patients, of whom 65 (10.2%) were sarcopenic. In adult female NAFLD patients, a great positive correlation of DII with the risk of sarcopenia was observed in the weighted logistics regression model [odds ratio (OR): 1.459, 95% confidence interval (CI): 1.013-2.103, P  = 0.045]. The RCS curve manifested a linear correlation between the two ( Pnonlinear  = 0.751). The threshold analysis demonstrated that when DII > 0, DII was positively linked with an elevated risk of sarcopenia (OR: 1.328, 95% CI: 1.030-1.722, P  = 0.030).

Conclusion: In adult female NAFLD patients, DII is positively linked with the risk of sarcopenia. Future research should further explore the mechanism of influence of DII on sarcopenia in NAFLD patients and evaluate whether improving eating habits can effectively reduce the occurrence of sarcopenia in women with NAFLD.