Comparative analysis of neurofilament light chain in Huntington's disease like 2 and Huntington's disease.

IF 2.1 Q3 NEUROSCIENCES Journal of Huntington's disease Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI:10.1177/18796397241300141
David G Anderson, Aline Ferreira-Correia, Filipe B Rodrigues, Lauren M Byrne, Edward J Wild, Amanda Krause
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引用次数: 0

Abstract

Huntington's disease-like 2 (HDL2) closely resembles Huntington's disease (HD) in clinical and pathological features. Neurofilament light chain (NfL) is an important biomarker in HD research and holds potential in HDL2. To evaluate NfL's utility in HDL2, a comparative analysis among HDL2 (n = 12), HD (n = 9), and unaffected controls (n = 9) was conducted. Employing a cross-sectional design, NfL levels were assessed in blood plasma. Concentrations were notably elevated in both HD and HDL2 groups compared to controls. HD patients displayed higher NfL levels than HDL2, possibly reflecting disease duration differences. NfL effectively distinguished HDL2 from controls, highlighting its promise as a possible biomarker in HDL2 research.

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来源期刊
CiteScore
4.80
自引率
9.70%
发文量
60
期刊最新文献
Lack of Evidence for Kynurenine Pathway Dysfunction in Huntington's Disease: CSF and Plasma Analyses from the HDClarity Study. Through their eyes: A retrospective mixed-methods study on the experiences and support needs of children growing up with a parent with Huntington's disease. Comparative analysis of neurofilament light chain in Huntington's disease like 2 and Huntington's disease. Frequency of depression in Huntington's disease: A systematic review and meta-analysis. Economic burden of Huntington's disease: A systematic review.
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