Standardised Methods for Developing Conceptual Frameworks for Placental Disorders of Pregnancy: Pre-Eclampsia and Stillbirth.

IF 4.3 1区医学 Q1 OBSTETRICS & GYNECOLOGY Bjog-An International Journal of Obstetrics and Gynaecology Pub Date : 2025-02-19 DOI:10.1111/1471-0528.18083

Terteel Elawad, Mai-Lei Woo Kinshella, Ellie Stokes, Kelly Pickerill, Elisa Dalle Piagge, Marianne Vidler, Ella Stanley, Marie-Laure Volvert, Jeffrey N Bone, Helen Elwell, Hiten D Mistry, Violet Mateljan, Eleni Tsigas, Veronique Filippi, Peter von Dadelszen, Hannah Blencowe, Laura A Magee

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Abstract

Background: Risk factors for the placental disorders of pregnancy (pre-eclampsia, fetal growth restriction, preterm birth, and stillbirth) are complex, frequently involving the interplay between clinical factors and wider social and environmental determinants of health. Biomarkers modulate the maternal and fetal responses to biological processes that underlie the development of placental disorders.

Objectives: To develop a standardised methodology to assess the importance of, and inter-relationships between, candidate risk factors for the various placental disorders.

Search strategy: Systematic searches were conducted using Medline, Embase, Health Technology Assessments, Database of Abstracts of Reviews of Effects, Cochrane Library databases, Google Scholar, and reference lists of retrieved papers.

Selection criteria: We deployed a hierarchy of reviews, systematic reviews, and cohort studies with at least 1000 participants (100 for biomarker studies), published in the prior decade.

Data collection and analysis: We assessed the strengths of association and quality of evidence linking risk factors with individual placental outcomes.

Conclusions: We have developed a standardised approach to assess the importance and inter-relatedness of putative risk factors for the placental disorders of pregnancy.

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制定妊娠胎盘疾病概念框架的标准化方法：先兆子痫和死产。

背景：妊娠胎盘疾病（先兆子痫、胎儿生长受限、早产和死胎）的危险因素是复杂的，通常涉及临床因素与健康的更广泛的社会和环境决定因素之间的相互作用。生物标志物调节母体和胎儿对胎盘疾病发展的生物学过程的反应。目的：开发一种标准化的方法来评估各种胎盘疾病候选危险因素的重要性和相互关系。检索策略：使用Medline、Embase、Health Technology Assessments、effect Reviews Abstracts Database、Cochrane Library数据库、谷歌Scholar和检索论文的参考文献列表进行系统检索。选择标准：我们采用了回顾、系统回顾和至少1000名参与者的队列研究（100名为生物标志物研究），这些研究发表于过去十年。数据收集和分析：我们评估了危险因素与个体胎盘结局的关联强度和证据质量。结论：我们已经开发了一种标准化的方法来评估妊娠胎盘疾病推定危险因素的重要性和相互关系。

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来源期刊

Bjog-An International Journal of Obstetrics and Gynaecology 医学-妇产科学

CiteScore

10.90

自引率

5.20%

发文量

345

审稿时长

3-6 weeks

期刊介绍： BJOG is an editorially independent publication owned by the Royal College of Obstetricians and Gynaecologists (RCOG). The Journal publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. Its aim is to publish the highest quality medical research in women''s health, worldwide.

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