{"title":"FGF21 keeps the thymus young","authors":"Yousuke Takahama","doi":"10.1038/s43587-025-00814-4","DOIUrl":null,"url":null,"abstract":"Age-associated thymic involution causes a reduction in the de novo production of T cells, which results in limited self-protective immunity and an elevated risk of autoimmunity. Two studies have now identified that the peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 4","pages":"534-535"},"PeriodicalIF":19.4000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00814-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Age-associated thymic involution causes a reduction in the de novo production of T cells, which results in limited self-protective immunity and an elevated risk of autoimmunity. Two studies have now identified that the peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance.
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