{"title":"Development of the Insulin Radioimmunoassay, the Watershed Moment in Diabetes Research: Revisiting 1960 Diabetes Classics by Berson and Yalow","authors":"David A. D’Alessio","doi":"10.2337/dbi24-0055","DOIUrl":null,"url":null,"abstract":"The discovery and development of the radioimmunoassay (RIA) for insulin by Berson and Yalow fundamentally changed biomedical science. The story of this accomplishment began with the pairing of brilliant scientists with complementary expertise who identified a key gap in knowledge they were able to bridge through a series of insightful experiments. Through a succession of important publications over 5 years of work, Berson and Yalow refined the approach to a novel method to measure insulin and demonstrated the power of this method in convincing clinical studies. This culminated in 1960, with three independent papers introducing the insulin RIA and demonstrating the utility in measuring circulating insulin in healthy and diseased states. Two of these papers were published in Diabetes—classics that are revisited here.","PeriodicalId":11376,"journal":{"name":"Diabetes","volume":"50 1","pages":""},"PeriodicalIF":6.2000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2337/dbi24-0055","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
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Abstract
The discovery and development of the radioimmunoassay (RIA) for insulin by Berson and Yalow fundamentally changed biomedical science. The story of this accomplishment began with the pairing of brilliant scientists with complementary expertise who identified a key gap in knowledge they were able to bridge through a series of insightful experiments. Through a succession of important publications over 5 years of work, Berson and Yalow refined the approach to a novel method to measure insulin and demonstrated the power of this method in convincing clinical studies. This culminated in 1960, with three independent papers introducing the insulin RIA and demonstrating the utility in measuring circulating insulin in healthy and diseased states. Two of these papers were published in Diabetes—classics that are revisited here.
期刊介绍：
Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes.
However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.
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