AgSbF6 Catalyzed Reduction of Nitroarenes by Phenylsilane to Anilines

Abstract

AgSbF₆-catalyzed activation of phenylsilane (PhSiH₃) enables the efficient reduction of nitroarenes to produce the corresponding anilines. This methodology operates under additive-free conditions, making it highly efficient, scalable, and compatible with a wide range of electronically diverse nitroarenes. The utility of this method is exemplified by employing a cheap, commercially available metal catalyst for the facile synthesis of various anilines. Furthermore, the methodology has been extended to the synthesis of intermediates for drug molecules, demonstrating its broad applicability.