RNAi technology development for weed control: all smoke and no fire?

IF 3.8 1区农林科学 Q1 AGRONOMY Pest Management Science Pub Date : 2025-02-21 DOI:10.1002/ps.8729

Silvia Panozzo, Andrea Milani, Serena Bordignon, Laura Scarabel, Serena Varotto

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Abstract

RNA interference (RNAi) technology, specifically Spray-Induced Gene Silencing (SIGS), holds potential as an innovative approach for selective weed control, promising environmentally friendly alternatives to traditional herbicides. Although the development of RNAi-based crop protection agents against pathogens, insects and viruses is advancing rapidly, RNAi-based weed control remains in the nascent stages, with challenges in gene target specificity and effective delivery mechanisms. It is potentially a game-changer in agriculture, yet SIGS's applicability is limited by the lack of scientific evidence. The overall aim of this review is to focus attention on critical points that need to be addressed to advance the knowledge about and development of RNAi herbicides, and overcome the poor progress achieved so far. Enhancing RNAi delivery methods and focusing on high impact weed species could transform SIGS into a viable tool for sustainable agriculture. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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杂草控制的RNAi技术发展：有烟无火？

RNA干扰（RNAi）技术，特别是喷雾诱导基因沉默（SIGS），作为一种有潜力的选择性杂草控制的创新方法，有望成为传统除草剂的环保替代品。尽管基于rnai的作物保护剂对病原体、昆虫和病毒的开发进展迅速，但基于rnai的杂草防治仍处于初级阶段，在基因靶点特异性和有效的递送机制方面存在挑战。它有可能改变农业的游戏规则，但由于缺乏科学证据，SIGS的适用性受到限制。本文综述的总体目的是关注需要解决的关键问题，以促进对RNAi除草剂的认识和开发，并克服迄今为止进展缓慢的问题。改进RNAi传递方法和专注于高影响杂草物种可以将SIGS转变为可持续农业的可行工具。©2025作者。《病虫害管理科学》由John Wiley &出版；我代表化学工业协会的儿子有限公司。

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.