{"title":"PIDA mediated oxidative annulation of aryl methyl ketones: a facile approach for the chemoselective synthesis of 5-substituted oxazoles.","authors":"Mohankumar Devaraju, Jagadeesh Prasad Dasappa","doi":"10.1039/d4ob01427h","DOIUrl":null,"url":null,"abstract":"<p><p>We have developed a simple and efficient protocol for the chemoselective synthesis of 5-substituted oxazoles <i>via</i> oxidative annulation of substituted acetophenones with NH<sub>4</sub>OAc and DMSO using PIDA as an effective oxidant. NH<sub>4</sub>OAc and DMSO act as less toxic one nitrogen and one carbon synthons, respectively. It is a metal-free, step and atom economical approach with good functional group tolerance and chemoselectivity.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01427h","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
We have developed a simple and efficient protocol for the chemoselective synthesis of 5-substituted oxazoles via oxidative annulation of substituted acetophenones with NH4OAc and DMSO using PIDA as an effective oxidant. NH4OAc and DMSO act as less toxic one nitrogen and one carbon synthons, respectively. It is a metal-free, step and atom economical approach with good functional group tolerance and chemoselectivity.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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