The Trend of Japanese Encephalitis in Uttar Pradesh, India.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Annals of African Medicine Pub Date : 2025-02-21 DOI:10.4103/aam.aam_185_24

Anuragani Verma, Shruti Radera, Amita Jain, Om Prakash, Anil Kumar Verma

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Abstract

Objective: Japanese encephalitis (JE) is one of the most important causes of viral encephalitis in Uttar Pradesh (UP). Over 5 years (2018-2022), this study aims to find out the seropositivity for JEV in cases presenting as AES.

Materials and methods: Over 5 years, 8131 cerebrospinal fluid and 504 serum samples were tested for anti-JEV Immunoglobulin M (IgM) antibodies by IgM antibody capture (MAC) enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's instructions (MAC ELISA kit developed by the National Institute of Virology, Pune, India.

Results: A total of 526 cases (6.09%) tested positive for anti-JEV IgM antibodies during the study periods. The number of JEV positives was high in 2018 (11.25%) but decreased gradually over the next 5 years (2019 (5.71%), 2020 (5.22%), 2021 (4.36%), and 2022 (2.91%). JE positivity is declining over time in UP, India. There is an age shift from children to adults. Men are more often affected than women.

Conclusion: Further JE-centric studies with an emphasis on immunization are required to determine the influence of vaccination on the incidence of Japanese encephalitis and the population shift among adults.

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Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

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0.90

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.