Ohauamines A-D, Structurally Unprecedented Tricyclic Depsi-tripeptides from the New Zealand Ascidian Pycnoclavella kottae.

IF 3.6 2区 生物学 Q2 CHEMISTRY, MEDICINAL Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-02-20 DOI:10.1021/acs.jnatprod.5c00033
Dan Chen, Florent Rouvier, Robert Keyzers, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Melissa M Cadelis, Brent R Copp
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Abstract

Four structurally unprecedented tricyclic depsi-tripeptides, ohauamines A-D (1-4), were isolated from the New Zealand endemic ascidian Pycnoclavella kottae. Planar structures were elucidated by extensive use of 1H-, 13C-, and 15N-based NMR experiments, with absolute configurations established by computational methods.

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ohaamines A-D,结构上前所未有的三环沉积三肽,来自新西兰海鞘。
从新西兰特有海鞘中分离到4个结构前所未有的三环沉积三肽ohaamines A-D(1-4)。平面结构通过广泛使用1H-, 13C-和15n -核磁共振实验来阐明,并通过计算方法建立绝对构型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.10
自引率
5.90%
发文量
294
审稿时长
2.3 months
期刊介绍: The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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