Mina Bagherifard, Amrit Kaur, Kamal E. S. Nassar, Neelam Tariq, Zois Syrgiannis and Ioannis Spanopoulos
{"title":"Development of amide-based molecular cages for the highly selective and sensitive detection of nicotine†","authors":"Mina Bagherifard, Amrit Kaur, Kamal E. S. Nassar, Neelam Tariq, Zois Syrgiannis and Ioannis Spanopoulos","doi":"10.1039/D5AY00206K","DOIUrl":null,"url":null,"abstract":"<p >Nicotine is a harmful sympathomimetic drug associated with serious health issues. Herein, a novel amide-based bistren-type cage, <strong>BiP-Am</strong>, has been developed for the selective fluorescence-based sensing of nicotine in human urine samples and cigarettes. The corresponding detection limit features a value of 0.4 nM, among the best reported in the literature. Selectivity experiments demonstrate that <strong>BiP-Am</strong> can efficiently detect nicotine in the presence of multiple interfering analytes such as sodium, potassium, urea and uric acid. A plausible mechanism has been proposed herein, revealing that nicotine is showing an inner-filter effect quenching the <strong>BiP-Am</strong> fluorescence emission. Our strategy poses a facile and versatile method for nicotine detection in portable applications.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 10","pages":" 2321-2325"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ay/d5ay00206k?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Methods","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/ay/d5ay00206k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Nicotine is a harmful sympathomimetic drug associated with serious health issues. Herein, a novel amide-based bistren-type cage, BiP-Am, has been developed for the selective fluorescence-based sensing of nicotine in human urine samples and cigarettes. The corresponding detection limit features a value of 0.4 nM, among the best reported in the literature. Selectivity experiments demonstrate that BiP-Am can efficiently detect nicotine in the presence of multiple interfering analytes such as sodium, potassium, urea and uric acid. A plausible mechanism has been proposed herein, revealing that nicotine is showing an inner-filter effect quenching the BiP-Am fluorescence emission. Our strategy poses a facile and versatile method for nicotine detection in portable applications.
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