Tumor infiltrating lymphocytes in primary melanoma are associated with a better prognosis

IF 2.7 3区医学 Q1 SURGERY American journal of surgery Pub Date : 2025-02-08 DOI:10.1016/j.amjsurg.2025.116243

Steven L. Morrison , Gang Han , Faith Elenwa , Stanley P. Leong , Mohammed Kashani-Sabet , Barbara Pockaj , Heidi E. Kosiorek , Richard L. White Jr. , Jonathan S. Zager , Jane L. Messina , Vernon Sondak , Cristina O'Donoghue , John Harrison Howard , Schlomo Schneebaum , Roger Olofsson Bagge , Jukes P. Namm , Carlos Garberoglio , Eli Avisar , Graham Fowler , Dale Han , John Vetto

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Abstract

Background

The relationship between tumor infiltrating lymphocytes (TIL) and survival in melanoma is poorly understood. We present a large multicenter study assessing the association between TIL and survival.

Methods

The Sentinel Lymph Node Working Group database was queried from 1993 to 2024 for cases with known TIL and survival data. TIL was analyzed dichotomously and stratified as non-brisk, brisk, and absent. Clinicopathologic factors were correlated with melanoma-specific survival (MSS), overall survival (OS), and recurrence-free survival (RFS).

Results

Among 4957 patients, TIL was present in 3980 (80.2 %) of patients. TIL was prognostic of MSS (p = 0.0033), OS (p = 0.0053), and RFS (p = 0.0011). In the stratified analysis, brisk TIL was more strongly associated with MSS, OS, and RFS than non-brisk TIL (all p < 0.04). Among patients with a positive sentinel lymph node, TIL was prognostic of MSS, OS, and RFS (all p < 0.03).

Conclusions

TIL is strongly predictive of survival in melanoma and may be useful in risk stratification when deciding whether risks of adjuvant therapy outweigh benefits for certain patients.

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原发性黑色素瘤浸润淋巴细胞预后较好。

背景：肿瘤浸润淋巴细胞（TIL）与黑色素瘤存活之间的关系尚不清楚。我们提出了一项大型多中心研究，评估TIL与生存之间的关系。方法：查询1993年至2024年前哨淋巴结工作组数据库中已知TIL和生存数据的病例。对TIL进行二分类和分层，分为不活跃、活跃和不存在。临床病理因素与黑色素瘤特异性生存期（MSS）、总生存期（OS）和无复发生存期（RFS）相关。结果：4957例患者中有3980例（80.2%）存在TIL。直到预后MSS (p = 0.0033),操作系统(p = 0.0053), RFS (p = 0.0011)。在分层分析中，与非快速TIL相比，快速TIL与MSS、OS和RFS的相关性更强（均为p）。结论：TIL可强烈预测黑色素瘤患者的生存，在确定某些患者辅助治疗的风险是否大于获益时，可能有助于进行风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.