Maarten J G Leening, Ching F Khan, Fang Zhu, Sunny S Singh, Maryam Kavousi, Eric J G Sijbrands, Yolanda B de Rijke, Daniel Bos
{"title":"Lipoprotein(a) immunoassays and their associations with coronary artery calcification and aortic valve calcification.","authors":"Maarten J G Leening, Ching F Khan, Fang Zhu, Sunny S Singh, Maryam Kavousi, Eric J G Sijbrands, Yolanda B de Rijke, Daniel Bos","doi":"10.1016/j.ahj.2025.02.008","DOIUrl":null,"url":null,"abstract":"<p><p>Lp(a) causes atherosclerosis and degenerative aortic valve disease, but concerns have risen that mass-based assays may be affected by isoform sizes and provide inaccurate estimates of Lp(a) exposure. We compared contemporary immunoturbidimetric assays reporting either mass-based (Randox) or molar-based (Roche) using data from 5129 unselected participants from the prospective population-based Rotterdam Study. We demonstrate that these immunoassays provide interchangeable Lp(a) measurements, and that associations with CT coronary artery calcium and aortic valve calcification were near-identical.</p>","PeriodicalId":7868,"journal":{"name":"American heart journal","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American heart journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ahj.2025.02.008","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Lp(a) causes atherosclerosis and degenerative aortic valve disease, but concerns have risen that mass-based assays may be affected by isoform sizes and provide inaccurate estimates of Lp(a) exposure. We compared contemporary immunoturbidimetric assays reporting either mass-based (Randox) or molar-based (Roche) using data from 5129 unselected participants from the prospective population-based Rotterdam Study. We demonstrate that these immunoassays provide interchangeable Lp(a) measurements, and that associations with CT coronary artery calcium and aortic valve calcification were near-identical.
期刊介绍：
The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.
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