Do antipsychotic medications work: An exploration using competency to stand trial as the functional outcome.

IF 4.1 3区 医学 Q2 CLINICAL NEUROLOGY CNS Spectrums Pub Date : 2025-02-21 DOI:10.1017/S1092852924002372
Ambarin Faizi, Barbara E McDermott, Katherine Warburton
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Abstract

This study explores the effectiveness of antipsychotic medications in restoring competency to stand trial in individuals with severe mental illness, particularly psychotic disorders. While antipsychotic medications are known for reducing symptoms of psychosis, this research focuses on their ability to improve functional outcomes necessary for competency to stand trial (CST). Among over 3,000 patients in California's forensic state hospital system, 86.5% were successfully restored to competency, with 98.8% discharged on antipsychotic medications. Patients on antipsychotic monotherapy demonstrated higher restoration rates compared to those requiring additional mood stabilizers, suggesting that more complex cases demand more intensive treatment. Delusional disorder, traditionally seen as more resistant to treatment, showed a high restoration rate of 93.8% with antipsychotic use.Our findings emphasize the pivotal role of antipsychotics in not only reducing symptoms but also in restoring critical functional abilities for participation in legal proceedings. The functional improvements they enable extend beyond the courtroom. Incorporation of antipsychotic medication as an integral evidence-based mechanism in facilitating community reintegration for individuals with severe mental illness supports the broader goal of transitioning individuals from the legal system back into society, consistent with the ultimate promise of deinstitutionalization.

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抗精神病药物是否有效:以能力接受审判作为功能性结果的探索。
本研究探讨了抗精神病药物在恢复严重精神疾病,特别是精神障碍患者出庭能力方面的有效性。虽然抗精神病药物以减轻精神病症状而闻名,但本研究的重点是它们改善受审能力(CST)所需的功能结果的能力。在加州法医州立医院系统的3000多名患者中,86.5%的人成功地恢复了能力,其中98.8%的人在服用抗精神病药物后出院。与那些需要额外的情绪稳定剂的患者相比,接受抗精神病药物单一治疗的患者显示出更高的恢复率,这表明更复杂的病例需要更强化的治疗。传统上被认为对治疗更有抵抗力的妄想障碍在使用抗精神病药后恢复率高达93.8%。我们的研究结果强调了抗精神病药物的关键作用,不仅在减轻症状,而且在恢复参与法律诉讼的关键功能能力。它们所带来的功能改进超越了法庭。将抗精神病药物作为一种完整的循证机制,促进严重精神疾病患者重新融入社区,支持将个人从法律体系转移回社会的更广泛目标,与去机构化的最终承诺相一致。
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来源期刊
CNS Spectrums
CNS Spectrums 医学-精神病学
CiteScore
6.20
自引率
6.10%
发文量
239
审稿时长
>12 weeks
期刊介绍: CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.
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