Effects of visual impairment and its restoration on electroencephalogram during walking in aged females.

IF 7.3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL Chinese Medical Journal Pub Date : 2025-03-20 Epub Date: 2025-02-21 DOI:10.1097/CM9.0000000000003549

Mingxin Ao, Hongshi Huang, Xuemin Li, Yingfang Ao

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Abstract

Background: Visual input significantly influences cerebral activity related to locomotor navigation, although the underlying mechanism remains unclear. This study aimed to analyze the effects of chronic visual impairment and its rehabilitation on sensorimotor integration during level walking in patients with age-related cataract.

Methods: This prospective case series enrolled 14 female patients (68.4 ± 4.7 years) with age-related cataract, scheduled for consecutive cataract surgeries at the Department of Ophthalmology in Peking University Third Hospital from June 2019 to June 2020. Electroencephalogram (EEG) signals during level walking were recorded using a portable EEG system before and 4 weeks after visual restoration. Walking speed was assessed using the Footscan system. Spectral power of the theta and alpha bands was analyzed with repeated-measures analysis of variance, with Assignment (rest and walking), Phase (preoperative and postoperative), and Electrode sites (F3, Fz, F4, O1, and O2) as within-subject factors.

Results: Compared to the visual impairment state, theta band power significantly decreased after visual restoration (13.16 ± 1.58 μV 2vs. 23.65 ± 3.48 μV 2 , P = 0.018). Theta activity was notably reduced during walking (17.24 ± 2.43 μV 2vs. 37.86 ± 6.62 μV 2 , P = 0.017), while theta power at rest was not significantly different between the two phases (9.44 ± 1.24 μV 2vs. 9.08 ± 1.74 μV 2 , P = 0.864). Changes in walking speed were correlated with alterations in theta power at electrode sites of O1 ( r = -0.574, P = 0.032) and O2 ( r = -0.648, P = 0.012). Alpha band power remained stable during walking and was unaffected by visual status.

Conclusions: Chronic visual impairment from age-related cataract triggers enhanced cerebral activation of sensorimotor integration to compensate for visual decline during locomotion. This cerebral over-activation is effectively alleviated by visual restoration.

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视觉障碍及其恢复对老年女性行走时脑电图的影响。

背景：视觉输入显著影响与运动导航相关的大脑活动，尽管潜在的机制尚不清楚。本研究旨在分析慢性视力损害及其康复对老年性白内障患者水平行走感觉运动整合的影响。方法：本前瞻性病例系列纳入14例年龄相关性白内障女性患者（68.4±4.7岁），计划于2019年6月至2020年6月在北京大学第三医院眼科连续行白内障手术。采用便携式脑电图仪记录视力恢复前和恢复后4周水平行走时的脑电图信号。使用Footscan系统评估步行速度。使用重复测量方差分析分析theta和alpha波段的频谱功率，将分配（休息和行走）、相位（术前和术后）和电极位置（F3、Fz、F4、O1和O2）作为受试者内因素。结果：与视力受损状态相比，视力恢复后theta波段功率显著降低（13.16±1.58 μV2vs）。23.65±3.48 μv2, p = 0.018)。步行时θ波活动明显降低（17.24±2.43 μV2vs）。（37.86±6.62 μV2, P = 0.017），静息时θ波功率（9.44±1.24 μV2vs）两相比较差异无统计学意义。（9.08±1.74 μv2, p = 0.864）。步行速度的变化与休息时O1 （r = -0.574, P = 0.032）和O2 （r = -0.648, P = 0.012）时theta功率的变化相关。α波段功率在行走过程中保持稳定，不受视觉状态的影响。结论：老年性白内障引起的慢性视力损害可触发大脑感觉运动整合的激活，以补偿运动过程中的视力下降。这种大脑过度激活可通过视觉恢复得到有效缓解。

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来源期刊

Chinese Medical Journal 医学-医学：内科

CiteScore

9.80

自引率

4.90%

发文量

19245

审稿时长

6 months

期刊介绍： The Chinese Medical Journal (CMJ) is published semimonthly in English by the Chinese Medical Association, and is a peer reviewed general medical journal for all doctors, researchers, and health workers regardless of their medical specialty or type of employment. Established in 1887, it is the oldest medical periodical in China and is distributed worldwide. The journal functions as a window into China’s medical sciences and reflects the advances and progress in China’s medical sciences and technology. It serves the objective of international academic exchange. The journal includes Original Articles, Editorial, Review Articles, Medical Progress, Brief Reports, Case Reports, Viewpoint, Clinical Exchange, Letter,and News,etc. CMJ is abstracted or indexed in many databases including Biological Abstracts, Chemical Abstracts, Index Medicus/Medline, Science Citation Index (SCI), Current Contents, Cancerlit, Health Plan & Administration, Embase, Social Scisearch, Aidsline, Toxline, Biocommercial Abstracts, Arts and Humanities Search, Nuclear Science Abstracts, Water Resources Abstracts, Cab Abstracts, Occupation Safety & Health, etc. In 2007, the impact factor of the journal by SCI is 0.636, and the total citation is 2315.