Low Grade Pulmonary Spindle Cell Neoplasm in a 30-Year-Old Asymptomatic Female: A Diagnostic Dilemma: A Case Report.

IF 0.8 Q4 RESPIRATORY SYSTEM Respirology Case Reports Pub Date : 2025-02-19 eCollection Date: 2025-02-01 DOI:10.1002/rcr2.70110

Jerica Eliesa Juarez, Albert Lim Rafanan, Matthew Go Yap

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Abstract

Pulmonary spindle cell carcinoma is a highly malignant rare variant of sarcomatoid lung carcinomas. This is a case of an asymptomatic 30-year-old Filipino female with an incidental finding of pulmonary nodules on chest x-ray. Patient was diagnosed with Wilms tumor at the age of 2, S/P nephrectomy with no documented recurrence thereafter. Computed tomography (CT) chest scan showed non-calcified fat density nodules in her right upper, middle and lower lobe. A positron emission tomography (PET) CT scan identified lobulated pulmonary mass with low-grade metabolic activity. Video Assisted Thoracic Surgery with wedge resection of the right lung was done. Final biopsy noted fibroepithelial lesions in the parenchyma which composed of bland spindle cells. ER, SMA, desmin, and caldesmon were diffusely positive consistent with a low-grade spindle cell neoplasm. Genetic testing showed CTNNB1 S45F subclonal mutations. No chemotherapy nor radiotherapy were done. Repeat PET CT of the whole body showed a decrease in size of the mass.

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来源期刊

Respirology Case Reports RESPIRATORY SYSTEM-

CiteScore

1.40

自引率

0.00%

发文量

178

审稿时长

8 weeks

期刊介绍： Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.