The effect of combined oral contraceptive pills on angiogenesis in endometriotic lesions.

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Hormones-International Journal of Endocrinology and Metabolism Pub Date : 2025-02-21 DOI:10.1007/s42000-025-00636-4

Siampalis Antonis, Papakonstantinou Efthymia, Keramida Maria, Panteris Eleftherios, Kalogeropoulos Sotiris, Georgopoulos Neoklis, Taniguchi Fuminori, Adonakis George, Harada Tasuku, Kaponis Apostolos

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引用次数: 0

Abstract

Purpose: Neoangiogenesis is necessary for adhesion and invasion of endometriotic lesions. We hypothesize that by blocking angiogenetic pathways we can suppress endometriosis. Oral contraceptive pills (OCs) are routinely used in endometriosis to suppress symptoms of the disease. In the current study, we attempt to evaluate the effects of OCs on various angiogenetic factors in women with endometriosis.

Methods: Sixty women with endometriosis were randomly divided into two groups. Group A consisted of 30 women who received OCs in a cyclical manner for 3 months before surgery and group B of 30 women who did not. Biopsy specimens of ovarian endometrioma were collected. We used qRT-PCR to study the mRNA expression levels of VEGF, TF, PAR-2, SP1, and FGF1.

Results: The levels of mRNA of all angiogenic factors were found to be elevated in women who received OCs compared with women who did not. This difference was statistically significant for VEGF, TF, FGF1, SP1 (p < 0.001), and PAR-2 (p = 0.046).

Conclusion: OC administration does not inhibit neoangiogenesis in endometriotic lesions; on the contrary, angiogenetic pathways might be upregulated.

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来源期刊

Hormones-International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.