The effect of combined oral contraceptive pills on angiogenesis in endometriotic lesions.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Hormones-International Journal of Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2025-02-21 DOI:10.1007/s42000-025-00636-4

Antonis Siampalis, Efthymia Papakonstantinou, Maria Keramida, Eleftherios Panteris, Sotiris Kalogeropoulos, Neoklis Georgopoulos, Fuminori Taniguchi, George Adonakis, Tasuku Harada, Apostolos Kaponis

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Abstract

Purpose: Neoangiogenesis is necessary for adhesion and invasion of endometriotic lesions. We hypothesize that by blocking angiogenetic pathways we can suppress endometriosis. Oral contraceptive pills (OCs) are routinely used in endometriosis to suppress symptoms of the disease. In the current study, we attempt to evaluate the effects of OCs on various angiogenetic factors in women with endometriosis.

Methods: Sixty women with endometriosis were randomly divided into two groups. Group A consisted of 30 women who received OCs in a cyclical manner for 3 months before surgery and group B of 30 women who did not. Biopsy specimens of ovarian endometrioma were collected. We used qRT-PCR to study the mRNA expression levels of VEGF, TF, PAR-2, SP1, and FGF1.

Results: The levels of mRNA of all angiogenic factors were found to be elevated in women who received OCs compared with women who did not. This difference was statistically significant for VEGF, TF, FGF1, SP1 (p < 0.001), and PAR-2 (p = 0.046).

Conclusion: OC administration does not inhibit neoangiogenesis in endometriotic lesions; on the contrary, angiogenetic pathways might be upregulated.

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联合口服避孕药对子宫内膜异位症病变血管生成的影响。

目的：新生血管生成是子宫内膜异位症病变粘连和侵袭的必要条件。我们假设通过阻断血管生成途径可以抑制子宫内膜异位症。口服避孕药（OCs）通常用于子宫内膜异位症，以抑制疾病的症状。在目前的研究中，我们试图评估OCs对子宫内膜异位症女性各种血管生成因子的影响。方法：60例子宫内膜异位症患者随机分为两组。A组包括30名术前3个月周期性接受OCs治疗的女性，B组包括30名未接受OCs治疗的女性。收集卵巢子宫内膜异位瘤活检标本。我们采用qRT-PCR方法研究VEGF、TF、PAR-2、SP1和FGF1的mRNA表达水平。结果：与未接受OCs治疗的女性相比，接受OCs治疗的女性所有血管生成因子mRNA水平均升高。VEGF、TF、FGF1、SP1的差异有统计学意义(p)。相反，血管生成途径可能被上调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormones-International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.