Roman Palitsky, Nicholas K Canby, Nicholas T Van Dam, Holly F Levin-Aspenson, Deanna M Kaplan, Jessica Maples-Keller, Charles L Raison, George H Grant, Boadie W Dunlop, Willoughby B Britton
{"title":"Leveraging meditation research for the study of psychedelic-related adverse effects.","authors":"Roman Palitsky, Nicholas K Canby, Nicholas T Van Dam, Holly F Levin-Aspenson, Deanna M Kaplan, Jessica Maples-Keller, Charles L Raison, George H Grant, Boadie W Dunlop, Willoughby B Britton","doi":"10.1080/09540261.2024.2420745","DOIUrl":null,"url":null,"abstract":"<p><p>Psychedelics have shown early evidence for a range of benefits and low harm profiles in extant research. However, adverse effects (AEs) research in psychedelics has been limited, leading to underspecified AE profiles, inconsistent measurement, and potential undercounting of AEs. The development of safe, effective psychedelic therapies and treatments for AEs when they occur requires a thorough assessment of psychedelic-related AEs, their phenomenology, risk factors, and longitudinal duration. This article proposes that research on meditation-related AEs, which overlap in important ways with the phenomenological and contextual characteristics of psychedelic-related AEs, has engaged many methodological challenges present in the study of psychedelic-related AEs. Thus, meditation-related AE research offers thematic and methodological insights that are valuable to psychedelic AE research. An integrative review of extant AE research in both psychedelics and meditation is provided, and an agenda for leveraging meditation research to advance the investigation of psychedelic AEs is recommended. This includes the utility of meditation-related AEs as a comparator condition for psychedelic-related AEs, as well as recommendations for the adoption of (1) detailed and comprehensive, (2) user-informed, (3) impact-based, (4) standardized, (5) unbiased, and (6) representative measures of AEs and (7) examining factors that influence their impacts and trajectories.</p>","PeriodicalId":51391,"journal":{"name":"International Review of Psychiatry","volume":"36 8","pages":"841-855"},"PeriodicalIF":3.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Review of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09540261.2024.2420745","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Psychedelics have shown early evidence for a range of benefits and low harm profiles in extant research. However, adverse effects (AEs) research in psychedelics has been limited, leading to underspecified AE profiles, inconsistent measurement, and potential undercounting of AEs. The development of safe, effective psychedelic therapies and treatments for AEs when they occur requires a thorough assessment of psychedelic-related AEs, their phenomenology, risk factors, and longitudinal duration. This article proposes that research on meditation-related AEs, which overlap in important ways with the phenomenological and contextual characteristics of psychedelic-related AEs, has engaged many methodological challenges present in the study of psychedelic-related AEs. Thus, meditation-related AE research offers thematic and methodological insights that are valuable to psychedelic AE research. An integrative review of extant AE research in both psychedelics and meditation is provided, and an agenda for leveraging meditation research to advance the investigation of psychedelic AEs is recommended. This includes the utility of meditation-related AEs as a comparator condition for psychedelic-related AEs, as well as recommendations for the adoption of (1) detailed and comprehensive, (2) user-informed, (3) impact-based, (4) standardized, (5) unbiased, and (6) representative measures of AEs and (7) examining factors that influence their impacts and trajectories.
期刊介绍:
The International Review of Psychiatry is the premier review journal in the field with a truly international authorship and readership. Each bimonthly issue is dedicated to a specific theme relevant to psychiatry, edited by recognized experts on the topic, who are selected by the Editors and the Editorial Board. Each issue provides in-depth, scholarly reviews of the topic in focus. The Journal reaches a broad international readership including clinicians, academics, educators, and researchers who wish to remain up-to-date with recent and rapid developments in various fields of psychiatry. It aims to be of value to trainees by choosing topics of relevance to career development, which are also suitable for clinicians for continuing professional development.