Clinical Reasoning: A 26-Year-Old Woman With Headache and Eosinophilia.

IF 8.5 1区 医学 Q1 CLINICAL NEUROLOGY Neurology Pub Date : 2025-03-25 Epub Date: 2025-02-21 DOI:10.1212/WNL.0000000000213434
Wilson Guo Wei Goh, Isaac Kah Siang Ng, Marcus Kai Xuan Tan, Clare Yoke Kum Fong, Christopher Yuan Kit Chua, Gabriel Zherong Yan, Jean-Marc Chavatte, Derek Tuck Loong Soon, Andrew Che-Fai Hui, Paul Ananth Tambyah, May Zin Myint
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Abstract

Headache accompanied by eosinophilia in blood or CSF presents a complex clinical challenge. We present a case of a 26-year-old woman with headache, peripheral eosinophilia with meningeal enhancement, and intracranial vasculopathy on imaging. This case illustrates a systematic approach to a patient with meningitis, peripheral eosinophilia, and cerebral vasculitis, which includes comprehensive clinical history taking and appropriate investigative workup to differentiate between infectious and noninfectious causes and timely tissue sampling to conclusively determine the causative agent.

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临床理由:一个26岁的女性头痛和嗜酸性粒细胞增多。
头痛伴血或脑脊液嗜酸性粒细胞增多是一个复杂的临床挑战。我们报告一位26岁的女性,有头痛、外周嗜酸性粒细胞增多伴脑膜增强及颅内血管病变的影像学表现。本病例说明了对脑膜炎、外周嗜酸性粒细胞增多症和脑血管炎患者的系统治疗方法,包括全面的临床病史和适当的调查工作,以区分感染性和非感染性原因,及时的组织取样以最终确定病原体。
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来源期刊
Neurology
Neurology 医学-临床神经学
CiteScore
12.20
自引率
4.00%
发文量
1973
审稿时长
2-3 weeks
期刊介绍: Neurology, the official journal of the American Academy of Neurology, aspires to be the premier peer-reviewed journal for clinical neurology research. Its mission is to publish exceptional peer-reviewed original research articles, editorials, and reviews to improve patient care, education, clinical research, and professionalism in neurology. As the leading clinical neurology journal worldwide, Neurology targets physicians specializing in nervous system diseases and conditions. It aims to advance the field by presenting new basic and clinical research that influences neurological practice. The journal is a leading source of cutting-edge, peer-reviewed information for the neurology community worldwide. Editorial content includes Research, Clinical/Scientific Notes, Views, Historical Neurology, NeuroImages, Humanities, Letters, and position papers from the American Academy of Neurology. The online version is considered the definitive version, encompassing all available content. Neurology is indexed in prestigious databases such as MEDLINE/PubMed, Embase, Scopus, Biological Abstracts®, PsycINFO®, Current Contents®, Web of Science®, CrossRef, and Google Scholar.
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