Dosimetric comparison of HyperArc, conventional noncoplanar VMAT, and Halcyon-based coplanar VMAT in hippocampal-sparing whole-brain radiotherapy.

IF 1.1 4区医学 Q4 ONCOLOGY Medical Dosimetry Pub Date : 2025-02-20 DOI:10.1016/j.meddos.2025.01.007

Zhen Li, Xin Yang, Huaqu Zeng, Jianrong Yu, Siming Zheng, Minying Li

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Abstract

To assess the dosimetric characteristics of HyperArc (HA), noncoplanar VMAT (NC-plan), and coplanar VMAT (HL3arc) in hippocampal-sparing whole-brain radiotherapy (WBRT). Twenty patients undergoing WBRT at our Hospital from June 2021 to March 2023 were selected. The dose parameters of organs at risk (OARs) were evaluated for all three groups, including D_100%, D_max, and D_mean of hippocampus, D_max to the lens, eyes, optic nerves, and chiasm, D_mean to the scalp and upper neck, and the dose volume parameters V_5Gy, V_10Gy, V_15Gy, V_20Gy for the upper neck. The D_98%, V_28.5Gy, D_2%, HI, CI, GI for PTV, as well as planning time, and beam-on time. HA had the lowest hippocampal D_max and D_mean. HA's scalp D_mean was lower than HL3arc (p = 0.007). HA's upper neck region D_mean and V_5-20Gy(cm³) were significantly higher than NC-VMAT and HL3arc. For PTV, HA's D₉₈ and V_28.5Gy were higher than NC-VMAT and HL3arc (p < 0.05). HA exhibited a significant advantage in terms of HI, CI and GI. The average planning times were 84.67, 17.30, and 20.40 minutes. Among the three treatment approaches, HA demonstrated the lowest bilateral hippocampal doses, but it exhibited the highest average dose and low-dose volume in the upper neck region, with the longest planning optimization process.

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评估超弧线（HA）、非共面VMAT（NC-plan）和共面VMAT（HL3arc）在海马区全脑放射治疗（WBRT）中的剂量学特性。选取了20名2021年6月至2023年3月在我院接受WBRT治疗的患者。评估了三组危险器官（OARs）的剂量参数，包括海马的D100%、Dmax和Dmean，晶状体、眼睛、视神经和脊髓的Dmax，头皮和上颈部的Dmean，以及上颈部的剂量体积参数V5Gy、V10Gy、V15Gy和V20Gy。PTV的D98%、V28.5Gy、D2%、HI、CI、GI以及计划时间和射束时间。HA 的海马 Dmax 和 Dmean 最低。HA 的头皮 Dmean 低于 HL3arc（p = 0.007）。HA 上颈部区域的 Dmean 和 V5-20Gy(cm3) 明显高于 NC-VMAT 和 HL3arc。在 PTV 方面，HA 的 D98 和 V28.5Gy 均高于 NC-VMAT 和 HL3arc（p < 0.05）。HA在HI、CI和GI方面具有明显优势。平均计划时间分别为 84.67 分钟、17.30 分钟和 20.40 分钟。在三种治疗方法中，HA 的双侧海马剂量最低，但其平均剂量和颈上区域的低剂量体积最高，规划优化过程最长。

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来源期刊

Medical Dosimetry 医学-核医学

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

34 days

期刊介绍： Medical Dosimetry, the official journal of the American Association of Medical Dosimetrists, is the key source of information on new developments for the medical dosimetrist. Practical and comprehensive in coverage, the journal features original contributions and review articles by medical dosimetrists, oncologists, physicists, and radiation therapy technologists on clinical applications and techniques of external beam, interstitial, intracavitary and intraluminal irradiation in cancer management. Articles dealing primarily with physics will be reviewed by a specially appointed team of experts in the field.