Dermatofibrosarcoma Protuberans Arising in a Digit: A Case Report.

IF 1 4区医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2025-05-01 Epub Date: 2025-02-19 DOI:10.1097/DAD.0000000000002948

Samantha Sun, Jordan Odom, Nathalie Ruiz, Patricia Moody

引用次数: 0

Abstract

Abstract: Dermatofibrosarcoma protuberans (DFSP) is a rare slow-growing soft tissue sarcoma that is usually found on the trunk or extremities. This report highlights an exceedingly rare case in which a DFSP arose on the digit of a 43-year-old man. Clinical and histologic analysis revealed an atypical CD34-positive tumor with differentials including DFSP and multiple similar entities. However, fluorescence in situ hybridization studies revealed a COL1A1 translocation to the platelet-derived growth factor B (22q13.1) locus, t(17;22)(q22;q13), confirming the diagnosis of DFSP. Although rare, this case highlights the importance of including DFSP on the differential in CD34-positive acral tumors, with cytogenetic analysis crucial for accurate diagnosis and treatment.

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手指隆突性皮肤纤维肉瘤1例报告。

摘要：隆突性皮肤纤维肉瘤（DFSP）是一种罕见的生长缓慢的软组织肉瘤，常见于躯干或四肢。本报告强调了一个极其罕见的情况下，其中一个DFSP出现在一个43岁的男子的手指。临床和组织学分析显示为非典型cd34阳性肿瘤，差异包括DFSP和多个类似实体。然而，荧光原位杂交研究显示COL1A1易位到血小板源性生长因子B （22q13.1）位点t(17;22)(q22;q13)，证实了DFSP的诊断。虽然罕见，但该病例强调了将DFSP纳入cd34阳性肢端肿瘤鉴别的重要性，细胞遗传学分析对于准确诊断和治疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians

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