Focal Oral Elastosis: Case Series, Proposed Nomenclature, and Literature Review.

IF 1 4区 医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI:10.1097/DAD.0000000000002920
Lama Alabdulaaly, Dahee Chung, Sook-Bin Woo
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Abstract

Abstract: Late-onset focal dermal elastosis is an uncommon elastic disorder seen in older individuals and biopsies demonstrate an increase in elastic fibers. Elastosis of the oral cavity is reported uncommonly. The aim of this study is to describe oral biopsies with similar histopathologic features to late-onset focal dermal elastosis and to introduce the term "focal oral elastosis." We included oral biopsies that showed increased elastic fibers confirmed by Verhoeff-van Gieson histochemical stain. We identified 6 oral biopsies with prominent elastosis. There were 4 men, and the median age was 64.5 years. Elastosis was present in 5 nodular lesions and 1 papule. Lesions occurred on the gingiva (33.3%), palatal mucosa (33.3%), buccal mucosa (16.7%), and upper lip (16.7%). Deposition of amorphic bluish/amphophilic material in the subepithelial areas was seen in all cases confirmed with the Verhoeff-van Gieson stain. Our case series demonstrates the presence of elastic fibers in reactive lesions such as oral fibromas.

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局灶性口腔弹性增生:病例系列、拟议的命名法和文献回顾。
摘要:迟发性局灶性皮肤弹性病是一种罕见的弹性疾病,见于老年人,活检显示弹性纤维增加。口腔弹性变形的报道并不多见。本研究的目的是描述具有与迟发性局灶性皮肤弹性症相似的组织病理学特征的口腔活检,并引入术语“局灶性口腔弹性症”。我们纳入了经verhoff -van Gieson组织化学染色证实弹性纤维增加的口腔活检。我们发现6例口腔活检有明显的弹性增生。男性4例,中位年龄64.5岁。5个结节和1个丘疹有弹性增生。病变发生在牙龈(33.3%)、腭黏膜(33.3%)、颊黏膜(16.7%)和上唇(16.7%)。所有病例经范霍夫-范吉森染色证实均可见上皮下区无定形的淡蓝色/两性物质沉积。我们的病例系列表明弹性纤维存在于反应性病变,如口腔纤维瘤。
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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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