Emergence, prevalence and evolution of porcine reproductive and respiratory syndrome virus 1 in China from 1994 to 2024

IF 2.4 3区医学 Q3 VIROLOGY Virology Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI:10.1016/j.virol.2025.110457

Yuejia Qiu , Ming Qiu , Shubin Li , Shubo Li , Jianzhong Zhu , Kegong Tian , Nanhua Chen

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Abstract

Porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) was first detected in Chinese swine herds during an epidemiological investigation since 1994. Even though PRRSV-1 has been existed in China for 30 years, much less attention was paid on PRRSV-1 than PRRSV-2. This review systematically evaluated the emergence, prevalence and evolution of Chinese PRRSV-1 from 1994 to 2024. Here we showed that PRRSV-1 has been detected in at least 28 regions of China, which can be divided into eight subgroups within subtype 1. During the evolution in Chinese swine herds, a large number of substitutions, insertions and deletions were identified. Recombination events were also commonly detected accompanying with nsp1-nsp3, nsp9-nsp10 and ORF2-ORF6 regions as the cross-over hotspots. Remarkably, Chinese PRRSV-1 isolates showed a trend of increasing in pathogenicity in recent years. At last, we discussed the differential detection methods and cross-protection strategies against PRRSV-1 isolates. Overall, PRRSV-1 has become one of the widely-spread viruses in China posing a significant threat to China's swine industry.

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1994 - 2024年中国猪繁殖与呼吸综合征病毒1型的出现、流行与演变

猪繁殖与呼吸综合征病毒1型（PRRSV-1）是1994年在中国猪群流行病学调查中首次发现的。尽管PRRSV-1在中国已经存在了30年，但人们对PRRSV-1的关注远远少于PRRSV-2。本文系统评价了1994 - 2024年中国PRRSV-1的出现、流行和演变情况。本研究表明，中国至少有28个地区检测到PRRSV-1，这些地区可分为1亚型内的8个亚群。在中国猪群的进化过程中，发现了大量的替换、插入和缺失。在交叉热点nsp1-nsp3、nsp9-nsp10和ORF2-ORF6区域也常检测到重组事件。值得注意的是，近年来中国PRRSV-1分离株的致病性呈上升趋势。最后讨论了PRRSV-1分离株的鉴别检测方法和交叉防护策略。总的来说，PRRSV-1已成为中国广泛传播的病毒之一，对中国养猪业构成重大威胁。

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.