Phototherapy: progress, challenges, and opportunities

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Science China Chemistry Pub Date : 2024-12-05 DOI:10.1007/s11426-024-2411-7

Xi Yuan, Jun-Liang Zhou, Lin Yuan, Jiangli Fan, Juyoung Yoon, Xiao-Bing Zhang, Xiaojun Peng, Weihong Tan

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Abstract

Phototherapy has emerged as a promising modality in modern medicine, attracting significant attention due to its non-invasiveness, exceptional spatiotemporal controllability, and reduced side effects. Advanced technologies have been developed in phototherapy, encompassing three main approaches: photodynamic therapy, photothermal therapy, and photoactivatable prodrug-based therapy. In this review, we present photosensitizers, photothermal agents, and photoactivatable prodrugs, along with photo-responsive carriers used in therapy. Subsequently, we discuss the advantages of phototherapy in combating cancer, infections, and other diseases. Additionally, we highlight the benefits of combining phototherapy with other treatments, as single-mode therapeutic modalities often fail to achieve satisfactory efficiency. Finally, we address the current challenges in developing effective phototherapy agents, particularly regarding their clinical applications. We believe that advancements in phototherapy will promote non-invasive theranostic techniques for clinical studies.

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光疗已成为现代医学中一种前景广阔的治疗方式，因其非侵入性、卓越的时空可控性和较低的副作用而备受关注。光疗领域已开发出先进技术，包括三种主要方法：光动力疗法、光热疗法和基于光活化原药的疗法。在本综述中，我们将介绍光敏剂、光热剂和光活化原药，以及用于治疗的光反应载体。随后，我们将讨论光疗法在抗击癌症、感染和其他疾病方面的优势。此外，我们还强调了光疗法与其他疗法相结合的好处，因为单一模式的治疗方法往往无法达到令人满意的疗效。最后，我们探讨了目前在开发有效光疗药物方面所面临的挑战，尤其是在临床应用方面。我们相信，光疗技术的进步将促进无创治疗技术在临床研究中的应用。

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.